First Author | Gout O | Year | 1988 |
Journal | Neurosci Lett | Volume | 87 |
Issue | 1-2 | Pages | 195-9 |
PubMed ID | 3380338 | Mgi Jnum | J:27488 |
Mgi Id | MGI:74973 | Doi | 10.1016/0304-3940(88)90169-3 |
Citation | Gout O, et al. (1988) Remyelination by transplanted oligodendrocytes of a demyelinated lesion in the spinal cord of the adult shiverer mouse. Neurosci Lett 87(1-2):195-9 |
abstractText | Fragments of normal newborn mouse central nervous system (CNS) were transplanted into the spinal cord of adult shiverer mice at distance of 1, 2 or 3 intervertebral spaces from a lysolecithin-induced demyelinating lesion. Remyelination by grafted oligodendrocytes was observed by electron microscopy (EM). This result showed the capability of grafted oligodendrocytes or precursor cells to migrate to a demyelinated lesion and to remyelinate naked axons in an adult host, even in presence of host spontaneous remyelination. |