| First Author | Huseby ES | Year | 1999 |
| Journal | J Immunol | Volume | 163 |
| Issue | 3 | Pages | 1115-8 |
| PubMed ID | 10415003 | Mgi Jnum | J:119201 |
| Mgi Id | MGI:3701534 | Doi | 10.4049/jimmunol.163.3.1115 |
| Citation | Huseby ES, et al. (1999) Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice. J Immunol 163(3):1115-8 |
| abstractText | Multiple sclerosis (MS) is believed to be an autoimmune disease mediated by T cells specific for CNS Ags. MS lesions contain both CD4+ and CD8+ T lymphocytes. The contribution of CD4+ T cells to CNS autoimmune disease has been extensively studied in an animal model of MS, experimental autoimmune encephalomyelitis. However, little is known about the role of autoreactive CD8+ cytotoxic T cells in MS or experimental autoimmune encephalomyelitis. We demonstrate here that myelin basic protein (MBP) is processed in vivo by the MHC class I pathway leading to a MBP79-87/Kk complex. The recognition of this complex by MBP-specific cytotoxic T cells leads to a high degree of tolerance in vivo. This study is the first to show that the pool of self-reactive lymphocytes specific for MBP contain MHC class I-restricted T cells whose response is regulated in vivo by the induction of tolerance. |
