| First Author | Rodewald HR | Year | 1999 |
| Journal | Proc Natl Acad Sci U S A | Volume | 96 |
| Issue | 26 | Pages | 15068-73 |
| PubMed ID | 10611339 | Mgi Jnum | J:59081 |
| Mgi Id | MGI:1350875 | Doi | 10.1073/pnas.96.26.15068 |
| Citation | Rodewald HR, et al. (1999) Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice. Proc Natl Acad Sci U S A 96(26):15068-73 |
| abstractText | Thymocytes and thymic dendritic cell (DC) lineages develop simultaneously and may originate from a common intrathymic progenitor. Mice deficient for two growth factor receptor molecules [c-kit and the common cytokine receptor gamma chain (gamma(c))] lack all thymocytes including T cell progenitors. Despite this lack of pro-T cells, thymic DC compartments were identified in c-kit(-)gamma(c)(-) mice. Thus, c-kit- and gamma(c)-mediated signals are not essential to generate thymic DCs. In addition, pro-T cells do not appear to be obligatory progenitors of thymic DCs, because DC development is dissociated from the generation of thymocytes in these mice. Thymic DCs in c-kit(-)gamma(c)(-) mice are phenotypically and functionally normal. In contrast to wild-type mice, however, thymic DCs in c-kit(-)gamma(c)(-) and, notably, in RAG-2-deficient mice are CD8alpha(neg/low), indicating that CD8alpha expression on thymic DCs is not independent of thymocytes developing beyond the 'RAG-block.' |
