| First Author | King DP | Year | 1997 |
| Journal | Genetics | Volume | 146 |
| Issue | 3 | Pages | 1049-60 |
| PubMed ID | 9215907 | Mgi Jnum | J:41383 |
| Mgi Id | MGI:893830 | Doi | 10.1093/genetics/146.3.1049 |
| Citation | King DP, et al. (1997) The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit. Genetics 146(3):1049-60 |
| abstractText | Clock is a semidominant mutation identified from an N- ethyl-N-nitrosourea mutagenesis screen in mice. Mice carrying the Clock mutation exhibit abnormalities of circadian behavior, including lengthening of endogenous period and loss of rhythmicity. To identify the gene affected by this mutation, we have generated a high- resolution genetic map (> 1800 meioses) of the Clock locus. We report that Clock is 0.7 cM distal of Kit on mouse chromosome 5. Mapping shows that Clock lies within the W-19H deletion. Complementation analysis of different Clock and W-19H compound genotypes indicates that the Clock mutation behaves as an antimorph. This antimorphic behavior of Clock strongly argues that Clock defines a gene centrally involved in the mammalian circadian system. |
