| First Author | Nagamine CM | Year | 1998 |
| Journal | Dev Biol | Volume | 196 |
| Issue | 1 | Pages | 24-32 |
| PubMed ID | 9527878 | Mgi Jnum | J:47046 |
| Mgi Id | MGI:1202527 | Doi | 10.1006/dbio.1997.8826 |
| Citation | Nagamine CM, et al. (1998) Ovotestes in B6-XXSxr sex-reversed mice. Dev Biol 196(1):24-32 |
| abstractText | The sex-reversed mutation Sxr results in XX males. In the absence of any other mutations, testis differentiation in XXSxr fetuses is Essentially normal and only caste report of an XXSxr fetus with ovotestes is in the literature. We report that 84% (21/25) of 13 days postcoitum XXSxr fetuses on the B6 inbred genomic background have ovotestes. Ovotestes were found in fetuses from both Sxr(a) and Sxr(b) variants. Examination of fetuses alder than 13 dpe suggests that the presence of ovotestes is transient in most fetuses. However, one overt hermaphrodite was identified after birth. The development of ovotestes is associated with the inbred background and is exacerbated by the dominant spotting oncogene allele Kit(W-42I). We propose that spreading of S-inactivation into the Sw region resulting in loss of Sry expression is more extensive in BB-Sxr strains. (C) 1998 Academic Press. |
