First Author | Ip CK | Year | 2021 |
Journal | STAR Protoc | Volume | 2 |
Issue | 2 | Pages | 100448 |
PubMed ID | 33912847 | Mgi Jnum | J:354438 |
Mgi Id | MGI:7734854 | Doi | 10.1016/j.xpro.2021.100448 |
Citation | Ip CK (2021) An optimized protocol for establishing a chronic stress model in mice. STAR Protoc 2(2):100448 |
abstractText | Chronic stress has adverse consequences on many organ systems and physiological processes. However, existing protocols show large variability in response and are not suitable for female mice. Here, we provide a step-by-step protocol for establishing a reliable chronic stress model in mice that can be used in a variety of physiological settings. This protocol has been tested to be effective to produce a consistent response to stress in several mouse strains (C57BL/6J, 129X1/SvJ, B6.V-Lepob/J) and both sexes. For complete details on the use and execution of this protocol, please refer to Ip et al. (2019). |