| First Author | MacDonald S | Year | 1998 |
| Journal | Neurosci Lett | Volume | 248 |
| Issue | 2 | Pages | 85-8 |
| PubMed ID | 9654348 | Mgi Jnum | J:107948 |
| Mgi Id | MGI:3622583 | Doi | 10.1016/s0304-3940(98)00312-7 |
| Citation | MacDonald S, et al. (1998) Expression of beta-endorphin and its receptors in the spinal cord of obese-diabetic ob/ob mice. Neurosci Lett 248(2):85-8 |
| abstractText | Immunocytochemistry was used to demonstrate the presence of beta-endorphin, and quantitative autoradiography with [125I]beta-endorphin was used to study beta-endorphin binding sites, in spinal cord of lean and obese diabetic ob/ob mice. The proportion of beta-endorphin-positive neurones was approximately 6-fold higher in the ventral horn, and 2-fold higher in the dorsal horn of ob/ob mice than in lean controls. The maximum density of beta-endorphin binding sites was significantly higher in the dorsal horn and intermediate zone of ob/ob mice. The Kd value for the binding was similar in the ventral horn and intermediate zone in lean and ob/ob mice, but slightly lower in the dorsal horn of ob/ob mice. The findings indicate upregulation of both beta-endorphin and its receptors in spinal neurones of ob/ob mice. |
