| First Author | Yeh YS | Year | 2016 |
| Journal | Biochem Biophys Res Commun | Volume | 478 |
| Issue | 3 | Pages | 1317-22 |
| PubMed ID | 27569282 | Mgi Jnum | J:239014 |
| Mgi Id | MGI:5824776 | Doi | 10.1016/j.bbrc.2016.08.119 |
| Citation | Yeh YS, et al. (2016) Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway. Biochem Biophys Res Commun 478(3):1317-22 |
| abstractText | Isoprenoids such as geranylgeranyl pyrophosphate (GGPP) influence various biological processes. Here we show that GGPP inhibits adipocyte differentiation via the liver X receptors (LXRs) pathway. Intracellular GGPP levels and GGPP synthase (Ggps) mRNA expression increases during adipocyte differentiation. Ggps expression also increases in white adipose tissue of obese mice. GGPP addition reduces the expression of adipogenic marker genes such as adipocyte fatty acid binding protein, peroxisome proliferator-activated receptor gamma, and insulin-stimulated glucose uptake. Similarly, over-expressing Ggps inhibits adipocyte differentiation. In contrast, Ggps knockdown promotes adipocyte differentiation. Inhibition of adipocyte differentiation by GGPP was partially reduced by LXR agonist T0901317. Furthermore, Ggps knockdown up-regulates LXR target genes during adipocyte differentiation. These results suggest that GGPP may act as an endogenous regulator of adipocyte differentiation and maturation through a mechanism partially dependent on the LXR pathway. |
