| First Author | Haller EW | Year | 1999 |
| Journal | Am J Physiol | Volume | 276 |
| Issue | 4 Pt 1 | Pages | E762-5 |
| PubMed ID | 10198314 | Mgi Jnum | J:54704 |
| Mgi Id | MGI:1335726 | Doi | 10.1152/ajpendo.1999.276.4.E762 |
| Citation | Haller EW, et al. (1999) The obese gene is expressed in lean littermates of the genetically obese mouse (C57BL/6J ob/ob). Am J Physiol 276(4 Pt 1):E762-5 |
| abstractText | Some individuals of the mixed group of ''lean'' littermates (+/ob and +/+) of(C57BL/6J ob/ob) often suggest phenotypic characteristics of ob/ob animals. Therefore, it was of interest to determine whether expression of the ob gene had physiological significance in +/ob animals. Body weight (BW),:fasting blood glucose (FBG), and body core temperature (T-r) were monitored between 62 and 364 days of age in +/+ and +/ob mice. Among females but not males, +/ob mice were heavier (P = 0.003) and FBG levels were greater (P = 0.04) than in +/+ animals. Comparison of T-r indicated differences suggesting falling T-r in +/ob but rising T-r in +/+ mice with age in males but not females. Multivariate analysis of variance yielded genotype effects for both males (P = .0.002) and females (P = 0.02). BW, FBG, and T-r alone were sufficient at the 75% level for genotypic characterization and separation of +/? animals as +/ob or +/+; clearly expression of the ob,:gene in heterozygotes of the +/ob animal may make the mixed +/? group inappropriate as lean controls. |
