| First Author | Liu YL | Year | 1997 |
| Journal | FEBS Lett | Volume | 411 |
| Issue | 2-3 | Pages | 351-5 |
| PubMed ID | 9271234 | Mgi Jnum | J:42130 |
| Mgi Id | MGI:1095216 | Doi | 10.1016/s0014-5793(97)00732-1 |
| Citation | Liu YL, et al. (1997) Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice. FEBS Lett 411(2-3):351-5 |
| abstractText | The ob gene product, leptin, causes significant and dose- dependent inhibition of basal and insulin-stimulated glycogen synthesis in isolated soleus muscle from ob/ob mice, and a smaller, non-significant inhibition in muscle from wild-type mice. Leptin had no inhibitory effect on glycogen synthesis in soleus muscle from the diabetic (db/db) mice, which lack the functional leptin receptor. The full-length leptin receptor (Ob-Rb), is expressed in soleus muscle of both ob/ob and wild-type mice, however with no detectable differences in expression level, These results suggest that hyperleptinaemia may attenuate insulin action on glucose storage in skeletal muscle. (C) 1997 Federation of European Biochemical Societies. |
