Other
12 Authors
- Jiang L,
- Ali A,
- Tao C,
- Ye R,
- Scherer PE,
- Holland WL,
- Zhu Y,
- Gordillo R,
- Shao M,
- Wang QA,
- Gupta RK,
- Lian Y
| First Author | Wang QA | Year | 2015 |
| Journal | Nat Cell Biol | Volume | 17 |
| Issue | 9 | Pages | 1099-111 |
| PubMed ID | 26280538 | Mgi Jnum | J:227352 |
| Mgi Id | MGI:5700268 | Doi | 10.1038/ncb3217 |
| Citation | Wang QA, et al. (2015) Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. Nat Cell Biol 17(9):1099-111 |
| abstractText | Pathological expansion of adipose tissue contributes to the metabolic syndrome. Distinct depots develop at various times under different physiological conditions. The transcriptional cascade mediating adipogenesis is established in vitro, and centres around a core program involving PPARgamma and C/EBPalpha. We developed an inducible, adipocyte-specific knockout system to probe the requirement of key adipogenic transcription factors at various stages of adipogenesis in vivo. C/EBPalpha is essential for all white adipogenic conditions in the adult stage, such as adipose tissue regeneration, adipogenesis in muscle and unhealthy expansion of white adipose tissue during high-fat feeding or due to leptin deficiency. Surprisingly, terminal embryonic adipogenesis is fully C/EBPalpha independent, but does however depend on PPARgamma; cold-induced beige adipogenesis is also C/EBPalpha independent. Moreover, C/EBPalpha is not vital for adipocyte survival in the adult stage. We reveal a surprising diversity of transcriptional signals required at different stages of adipogenesis in vivo. |
