| First Author | Baazim H | Year | 2019 |
| Journal | Nat Immunol | Volume | 20 |
| Issue | 6 | Pages | 701-710 |
| PubMed ID | 31110314 | Mgi Jnum | J:282404 |
| Mgi Id | MGI:6380818 | Doi | 10.1038/s41590-019-0397-y |
| Citation | Baazim H, et al. (2019) CD8(+) T cells induce cachexia during chronic viral infection. Nat Immunol 20(6):701-710 |
| abstractText | Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC). In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8(+) T cells in IAC. Cytokines linked to cancer-associated cachexia did not contribute to IAC. Instead, virus-specific CD8(+) T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores. These changes occurred at a time point that preceded the peak of the CD8(+) T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming. Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8(+) T cells in IAC. |
