| First Author | Quail DF | Year | 2017 |
| Journal | Nat Cell Biol | Volume | 19 |
| Issue | 8 | Pages | 974-987 |
| PubMed ID | 28737771 | Mgi Jnum | J:246104 |
| Mgi Id | MGI:5921755 | Doi | 10.1038/ncb3578 |
| Citation | Quail DF, et al. (2017) Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF. Nat Cell Biol 19(8):974-987 |
| abstractText | Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonstrate that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour. The increase in lung neutrophils translates to increased breast cancer metastasis to this site, in a GM-CSF- and IL5-dependent manner. Importantly, weight loss is sufficient to reverse this effect, and reduce serum levels of GM-CSF and IL5 in both mouse models and humans. Our data indicate that special consideration of the obese patient population is critical for effective management of cancer progression. |
