| First Author | Ponnusamy S | Year | 2017 |
| Journal | FASEB J | Volume | 31 |
| Issue | 1 | Pages | 266-281 |
| PubMed ID | 27733447 | Mgi Jnum | J:267557 |
| Mgi Id | MGI:6267657 | Doi | 10.1096/fj.201600787RR |
| Citation | Ponnusamy S, et al. (2017) Pharmacologic activation of estrogen receptor beta increases mitochondrial function, energy expenditure, and brown adipose tissue. FASEB J 31(1):266-281 |
| abstractText | Most satiety-inducing obesity therapeutics, despite modest efficacy, have safety concerns that underscore the need for effective peripherally acting drugs. An attractive therapeutic approach for obesity is to optimize/maximize energy expenditure by increasing energy-utilizing thermogenic brown adipose tissue. We used in vivo and in vitro models to determine the role of estrogen receptor beta (ER-beta) and its ligands on adipose biology. RNA sequencing and metabolomics were used to determine the mechanism of action of ER-beta and its ligands. Estrogen receptor beta (ER-beta) and its selective ligand reprogrammed preadipocytes and precursor stem cells into brown adipose tissue and increased mitochondrial respiration. An ER-beta-selective ligand increased markers of tricarboxylic acid-dependent and -independent energy biogenesis and oxygen consumption in mice without a concomitant increase in physical activity or food consumption, all culminating in significantly reduced weight gain and adiposity. The antiobesity effects of ER-beta ligand were not observed in ER-beta-knockout mice. Serum metabolite profiles of adult lean and juvenile mice were comparable, while that of adult obese mice was distinct, indicating a possible impact of obesity on age-dependent metabolism. This phenotype was partially reversed by ER-beta-selective ligand. These data highlight a new role for ER-beta in adipose biology and its potential to be a safer alternative peripheral therapeutic target for obesity.-Ponnusamy, S., Tran, Q. T., Harvey, I., Smallwood, H. S., Thiyagarajan, T., Banerjee, S., Johnson, D. L., Dalton, J. T., Sullivan, R. D., Miller, D. D., Bridges, D., Narayanan, R. Pharmacologic activation of estrogen receptor beta increases mitochondrial function, energy expenditure, and brown adipose tissue. |
