| First Author | Matsusue K | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 14 | Pages | 2277-81 |
| PubMed ID | 24857376 | Mgi Jnum | J:211650 |
| Mgi Id | MGI:5575812 | Doi | 10.1016/j.febslet.2014.05.012 |
| Citation | Matsusue K, et al. (2014) Hepatic PPARgamma and LXRalpha independently regulate lipid accumulation in the livers of genetically obese mice. FEBS Lett 588(14):2277-81 |
| abstractText | The nuclear hormone receptors liver X receptor alpha (LXRalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma) play key roles in the development of fatty liver. To determine the link between hepatic PPARgamma and LXRalpha signaling and the development of fatty liver, a LXRalpha-specific ligand, T0901317, was administered to normal OB/OB and genetically obese (ob/ob) mice lacking hepatic PPARgamma (Ppargamma(DeltaH)). In ob/ob-Ppargamma(DeltaH) and OB/OB-Ppargamma(DeltaH) mice, as well as ob/ob-Ppargamma(WT) and OB/OB-Ppargamma(WT) mice, the liver weights and hepatic triglyceride levels were markedly increased in response to T0901317 treatment. These results suggest that hepatic PPARgamma and LXRalpha signals independently contribute to the development of fatty liver. |
