| First Author | Xu L | Year | 2015 |
| Journal | Genom Data | Volume | 5 |
| Pages | 326-8 | PubMed ID | 26484280 |
| Mgi Jnum | J:355988 | Mgi Id | MGI:7762080 |
| Doi | 10.1016/j.gdata.2015.07.003 | Citation | Xu L, et al. (2015) Gene expression profile in the fat tissue of Fsp27 deficient mice. Genom Data 5:326-8 |
| abstractText | Fsp27 is a lipid droplet-associated protein almost exclusively expressed in adipocytes where it facilitates unilocular lipid droplet formation. In mice, Fsp27 deficiency is associated with increased basal lipolysis, browning of white fat and a healthy metabolic profile, whereas energetically challenged Fsp27 deficient mice (ob/ob/Fsp27 (-/-)) show dramatically reduced fat mass, hepatic steatosis and insulin resistance which represents a typical lipodystrophy phenotype. Here, we investigate the effect of Fsp27 depletion on the gene expression of gonadal white adipose tissue (GWAT) under normal or energetically challenged condition (Fsp27 (-/-) vs Wild type; ob/ob/Fsp27 (-/-) vs ob/ob). We systematically analyzed the change in signaling pathway in Fsp27 deficient mice. The raw data have been deposited into Gene Expression Omnibus (GEO): GSE59807 and GSE22693. |
