| First Author | Garcia J | Year | 2018 |
| Journal | FEBS Lett | Volume | 592 |
| Issue | 6 | Pages | 916-927 |
| PubMed ID | 29430655 | Mgi Jnum | J:261169 |
| Mgi Id | MGI:6154470 | Doi | 10.1002/1873-3468.13005 |
| Citation | Garcia J, et al. (2018) Obesity and steatosis promotes mitochondrial remodeling that enhances respiratory capacity in the liver of ob/ob mice. FEBS Lett 592(6):916-927 |
| abstractText | We investigated if obesity/steatosis promotes mitochondrial remodeling in the liver of ob/ob mice (an obesity model). Liver mitochondria from ob/ob mice (21 weeks with significant steatosis) had ~ 2-fold increases in state III respiration compared with control (C57BL/6J, C57BL/6NJ) for all respiratory substrates examined (glutamate/malate, succinate, octanoate, and glycerol 3-phosphate). A corresponding 2-fold increase in the expression of respiratory complexes (I, IV, and V) and other respiratory proteins (glycerol phosphate dehydrogenase-2 and medium-chain acyl-coenzyme A dehydrogenase) occur in liver mitochondria of mature ob/ob mice. Conversely, respiration in liver mitochondria from young ob/ob mice (6 weeks) does not differ from control with any respiratory substrates examined. Overall, mitochondrial remodeling that enhances respiration increases with obesity/steatosis in the liver of ob/ob mice. |
