| First Author | Sekiya M | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 387 |
| Issue | 3 | Pages | 511-5 |
| PubMed ID | 19619509 | Mgi Jnum | J:152537 |
| Mgi Id | MGI:4359102 | Doi | 10.1016/j.bbrc.2009.07.078 |
| Citation | Sekiya M, et al. (2009) Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice. Biochem Biophys Res Commun 387(3):511-5 |
| abstractText | It has long been a matter of debate whether the hormone-sensitive lipase (HSL)-mediated lipolysis in pancreatic beta-cells can affect insulin secretion through the alteration of lipotoxicity. We generated mice lacking both leptin and HSL Lep(ob/ob)/HSL(-/-) and explored the role of HSL in pancreatic beta-cells in the setting of obesity. Lep(ob/ob)/HSL(-/-) developed elevated blood glucose levels and reduced plasma insulin levels compared with Lep(ob/ob)/HSL(+/+) in a fed state, while the deficiency of HSL did not affect glucose homeostasis in Lep(+/+) background. The deficiency of HSL exacerbated the accumulation of triglycerides in Lep(ob/ob) islets, leading to reduced glucose-stimulated insulin secretion. The deficiency of HSL also diminished the islet mass in Lep(ob/ob) mice due to decreased cell proliferation. In conclusion, HSL affects insulin secretary capacity especially in the setting of obesity. |
