| First Author | Hager-Theodorides AL | Year | 2005 |
| Journal | Blood | Volume | 106 |
| Issue | 4 | Pages | 1296-304 |
| PubMed ID | 15855276 | Mgi Jnum | J:117284 |
| Mgi Id | MGI:3695957 | Doi | 10.1182/blood-2005-03-0998 |
| Citation | Hager-Theodorides AL, et al. (2005) The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. Blood 106(4):1296-304 |
| abstractText | Glioblastoma 3 (Gli3) is a transcription factor involved in patterning and oncogenesis. Here, we demonstrate a role for Gli3 in thymocyte development. Gli3 is differentially expressed in fetal CD4- CD8- double-negative (DN) thymocytes and is most highly expressed at the CD44+ CD25- DN (DN1) and CD44- CD25- (DN4) stages of development but was not detected in adult thymocytes. Analysis of null mutants showed that Gli3 is involved at the transitions from DN1 to CD44+ CD25+ DN (DN2) cell and from DN to CD4+ CD8+ double-positive (DP) cell. Gli3 is required for differentiation from DN to DP thymocyte, after pre-T-cell receptor (TCR) signaling but is not necessary for pre-TCR-induced proliferation or survival. The effect of Gli3 was dose dependent, suggesting its direct involvement in the transcriptional regulation of genes controlling T-cell differentiation during fetal development. |
