| First Author | Orme JJ | Year | 2016 |
| Journal | PLoS One | Volume | 11 |
| Issue | 8 | Pages | e0161682 |
| PubMed ID | 27548498 | Mgi Jnum | J:251662 |
| Mgi Id | MGI:6099853 | Doi | 10.1371/journal.pone.0161682 |
| Citation | Orme JJ, et al. (2016) Leukocyte Beta-Catenin Expression Is Disturbed in Systemic Lupus Erythematosus. PLoS One 11(8):e0161682 |
| abstractText | Wnt/beta-catenin signaling is relatively understudied in immunity and autoimmunity. beta-catenin blocks inflammatory mediators and favors tolerogenic dendritic cell (DC) phenotypes. We show here that leukocytes from lupus-prone mice and SLE patients express diminished beta-catenin transcriptional activity, particularly in myeloid cells, although other leukocytes revealed similar trends. Serum levels of DKK-1, an inhibitor under transcriptional control of Wnt/beta-catenin, were also decreased in lupus-prone mice. Surprisingly, however, preemptive deletion of beta-catenin from macrophages appears to have no effect on lupus development, even in mice with varying genetic loads for lupus. Although myeloid-specific loss of beta-catenin does not seem to be important for lupus development, the potential role of this transcription factor in other leukocytes and renal cells remain to be elucidated. |
