| First Author | Moran ST | Year | 2007 |
| Journal | J Immunol | Volume | 179 |
| Issue | 1 | Pages | 195-200 |
| PubMed ID | 17579038 | Mgi Jnum | J:143155 |
| Mgi Id | MGI:3822986 | Doi | 10.4049/jimmunol.179.1.195 |
| Citation | Moran ST, et al. (2007) Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. J Immunol 179(1):195-200 |
| abstractText | NF-kappaB1 and Notch2 are both required for the development of marginal zone (MZ) B cells. Analysis of B lymphocyte development in mice that are doubly heterozygous at the Notch2 and NF-kappaB1 loci revealed synergism between Notch2 and NF-kappaB1 during MZ B cell development. Two known transcriptional targets of the Notch pathway, Hes-5 and Deltex-1, were found to be preferentially expressed in MZ B cells and regulated by NF-kappaB1. These studies provide in vivo evidence for a genetic interaction between the Notch and NF-kappaB pathways. |
