| First Author | Fieser TM | Year | 1984 |
| Journal | Cell Immunol | Volume | 87 |
| Issue | 2 | Pages | 708-13 |
| PubMed ID | 6235926 | Mgi Jnum | J:7541 |
| Mgi Id | MGI:56011 | Doi | 10.1016/0008-8749(84)90040-6 |
| Citation | Fieser TM, et al. (1984) Abrogation of murine lupus by the xid gene is associated with reduced responsiveness of B cells to T-cell-helper signals. Cell Immunol 87(2):708-13 |
| abstractText | Introduction of the xid genetic mutation into strains of mice (NZB, MRL/1, BXSB), which are normally susceptible to a lupus-like disorder, significantly delays the onset of disease and reduces the polyclonal B-cell activation characteristic of the lupus-prone strains. Evidence is presented here which shows that B cells from NZB and MRL/1 mice which carry the xid mutation have drastically reduced responses to T-cell-derived B-cell-growth- and differentiation-inducing activities. These results are in accord with a theory that acceleration of lupus onset may be due to overproduction of and/or increased responsiveness to B-cell activation signals. |
