Primary Identifier | MGI:7587821 | Allele Type | Endonuclease-mediated |
Attribute String | Hypomorph | Gene | Higd1c |
Inheritance Mode | Not Specified | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
molecularNote | CRISPR-cas9 mediated recombination using gRNAs targeting exon 3 created a 1 bp deletion resulting in a frameshift mutation. Levels of mRNA are reduced by 40-90% in the carotid body and kidneys from homozygous mice. |