| First Author | Sansom OJ | Year | 2003 |
| Journal | Nat Genet | Volume | 34 |
| Issue | 2 | Pages | 145-7 |
| PubMed ID | 12730693 | Mgi Jnum | J:83087 |
| Mgi Id | MGI:2656693 | Doi | 10.1038/ng1155 |
| Citation | Sansom OJ, et al. (2003) Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet 34(2):145-7 |
| abstractText | Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance. |
