| First Author | Taketo MM | Year | 2006 |
| Journal | Cancer Sci | Volume | 97 |
| Issue | 5 | Pages | 355-61 |
| PubMed ID | 16630131 | Mgi Jnum | J:116407 |
| Mgi Id | MGI:3694271 | Doi | 10.1111/j.1349-7006.2006.00190.x |
| Citation | Taketo MM (2006) Mouse models of gastrointestinal tumors. Cancer Sci 97(5):355-61 |
| abstractText | The laboratory mouse (Mus musculus) has become one of the best model animal species in biomedical research today because of its abundant genetic/genomic information, and easy mutagenesis using transgenic and gene knockout technology. Genetically engineered mice have become essential tools in both mechanistic studies and drug development. In this article I will review recent topics in gastrointestinal cancer model mice, with emphasis on the results obtained in our laboratory. They include: (i) mouse models for familial adenomatous polyposis (Apc mutant mice; modifier genes of Apc intestinal polyposis; stabilizing beta-catenin mutant mice); (ii) mouse models for colon cancer (mouse models for hereditary non-polyposis colon cancer; additional mutations in Apc mutant mice; models with mutations in other genes; models for colon cancer associated with inflammatory bowel diseases); and (iii) mouse models for gastric cancer. |
