| First Author | Soncin I | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 582 |
| PubMed ID | 29422500 | Mgi Jnum | J:257961 |
| Mgi Id | MGI:6119357 | Doi | 10.1038/s41467-018-02834-8 |
| Citation | Soncin I, et al. (2018) The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. Nat Commun 9(1):582 |
| abstractText | Circulating CCR2(+) monocytes are crucial for maintaining the adult tissue-resident F4/80(hi)MHCII(hi) macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80(hi)MHCII(low) macrophages, which are the most abundant F4/80(hi) cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80(hi) cells. In colon adenomas of Apc(Min/+) mice, F4/80(hi)MHCII(low) macrophages are not only preserved, but become the dominant subpopulation among tumour-resident macrophages during tumour progression. Furthermore, these pro-tumoural F4/80(hi)MHCII(low) and F4/80(hi)MHCII(hi) macrophages can self-renew in the tumour and maintain their numbers mostly independent from bone marrow contribution. Analyses of colon adenomas indicate that CSF1 may be a key facilitator of macrophage self-renewal. In summary, the tumour microenvironment creates an isolated niche for tissue-resident macrophages that favours macrophage survival and self-renewal. |
