Other
14 Authors
- Wattenberg B,
- Haribabu B,
- Zhang HG,
- Guo H,
- Zhuang X,
- Norris J,
- Zhang L,
- Wang Q,
- Deng Z,
- Tseng M,
- Yan J,
- Miller D,
- Mu J,
- Egilmez NK
| First Author | Deng Z | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 6956 | PubMed ID | 25907800 |
| Mgi Jnum | J:222801 | Mgi Id | MGI:5645616 |
| Doi | 10.1038/ncomms7956 | Citation | Deng Z, et al. (2015) Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. Nat Commun 6:6956 |
| abstractText | Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDENs (intestinal mucosa-derived exosome-like nanoparticles) containing elevated levels of sphingosine-1-phosphate, CCL20 and prostaglandin E2 (PGE2). CCL20 and PGE2 are required for the recruitment and proliferation, respectively, of Th17 cells, and these processes also involve the MyD88-mediated pathway. By influencing the recruitment and proliferation of Th17 cells in the intestine, IDENs promote colon cancer. We demonstrate the biological effect of sphingosine-1-phosphate contained in IDENs on tumour growth in spontaneous and transplanted colon cancer mouse models. These findings provide deeper insights into how host-microbe relationships are mediated by particles secreted from both bacterial and host cells. |
