| First Author | Gupta RA | Year | 2004 |
| Journal | Nat Med | Volume | 10 |
| Issue | 3 | Pages | 245-7 |
| PubMed ID | 14758356 | Mgi Jnum | J:88127 |
| Mgi Id | MGI:3029148 | Doi | 10.1038/nm993 |
| Citation | Gupta RA, et al. (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 10(3):245-7 |
| abstractText | We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth. |
