| First Author | Harman FS | Year | 2004 |
| Journal | Nat Med | Volume | 10 |
| Issue | 5 | Pages | 481-3 |
| PubMed ID | 15048110 | Mgi Jnum | J:90217 |
| Mgi Id | MGI:3042697 | Doi | 10.1038/nm1026 |
| Citation | Harman FS, et al. (2004) Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. Nat Med 10(5):481-483 |
| abstractText | Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis. |
