| First Author | Mahmoud NN | Year | 1998 |
| Journal | Surgery | Volume | 124 |
| Issue | 2 | Pages | 225-31 |
| PubMed ID | 9706142 | Mgi Jnum | J:50316 |
| Mgi Id | MGI:1303130 | Citation | Mahmoud NN, et al. (1998) Aspirin prevents tumors in a murine model of familial adenomatous polyposis. Surgery 124(2):225-31 |
| abstractText | BACKGROUND: Both human and murine studies suggest that anti-inflammatory drugs prevent intestinal neoplasia. The purpose of this study was to investigate the role of aspirin as a chemopreventive agent for colorectal cancer. METHODS: We administered aspirin to the Min/+ mouse, an animal with a germline mutation in Apc, a gene that is essential for normal epithelial cell growth and differentiation. Apc mutation increases cytoplasmic beta-catenin, a regulatory protein associated with the cytoskeleton. Min/+ mice develop multiple intestinal adenomas and exhibit altered cell growth in the preneoplastic intestinal epithelium. RESULTS: Aspirin decreased the rate of tumor formation in Min/+ mice by 44%. Aspirin also normalized enterocyte growth by increasing apoptosis and proliferation in the preneoplastic intestinal mucosa. Finally, aspirin produced a decrease in intracellular beta-catenin levels, suggesting that modulation of this protein is associated with tumor prevention. CONCLUSIONS: These data confirm a role for aspirin in suppression of Apc-associated intestinal carcinogenesis. |
