| First Author | De Santis S | Year | 2020 |
| Journal | Int J Mol Sci | Volume | 21 |
| Issue | 8 | PubMed ID | 32340123 |
| Mgi Jnum | J:335864 | Mgi Id | MGI:7485912 |
| Doi | 10.3390/ijms21082972 | Citation | De Santis S, et al. (2020) Winnie-APC(Min/+) Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation. Int J Mol Sci 21(8) |
| abstractText | (1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) with Apc(Min/+) mice. (3) Results: The resulting Winnie-Apc(Min/+) model combines an inflammatory background with a genetic predisposition to small intestinal polyposis. Winnie-Apc(Min/+) mice show an early occurrence of inflammatory signs and dysplastic lesions in the distal colon with a specific molecular signature. (4) Conclusion: The Winnie-Apc(Min/+) model is a perfect model to demonstrate that chronic inflammation represents a crucial risk factor for the onset and progression of tumoral lesions in individuals genetically predisposed to CRC. |
