| First Author | Chinen T | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 11 | Pages | 1322-1333 |
| PubMed ID | 27595233 | Mgi Jnum | J:237689 |
| Mgi Id | MGI:5816496 | Doi | 10.1038/ni.3540 |
| Citation | Chinen T, et al. (2016) An essential role for the IL-2 receptor in Treg cell function. Nat Immunol 17(11):1322-1333 |
| abstractText | Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by Treg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the Treg cell lineage-specification factor Foxp3, which has confounded experimental efforts to understand the role of IL-2R expression and signaling in the suppressor function of Treg cells. Using genetic gain- and loss-of-function approaches, we found that capture of IL-2 was dispensable for the control of CD4+ T cells but was important for limiting the activation of CD8+ T cells, and that IL-2R-dependent activation of the transcription factor STAT5 had an essential role in the suppressor function of Treg cells separable from signaling via the T cell antigen receptor. |
