| First Author | Roy HK | Year | 2001 |
| Journal | Br J Cancer | Volume | 84 |
| Issue | 10 | Pages | 1412-6 |
| PubMed ID | 11355956 | Mgi Jnum | J:69899 |
| Mgi Id | MGI:2135720 | Doi | 10.1054/bjoc.2001.1807 |
| Citation | Roy HK, et al. (2001) Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation. Br J Cancer 84(10):1412-6 |
| abstractText | Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with concomitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention. Copyright 2001 Cancer Research Campaign. |
