| First Author | Hariri LP | Year | 2006 |
| Journal | Lasers Surg Med | Volume | 38 |
| Issue | 4 | Pages | 305-13 |
| PubMed ID | 16596657 | Mgi Jnum | J:115751 |
| Mgi Id | MGI:3692151 | Doi | 10.1002/lsm.20305 |
| Citation | Hariri LP, et al. (2006) Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model. Lasers Surg Med 38(4):305-13 |
| abstractText | BACKGROUND AND OBJECTIVES: The diagnostic feasibility of optical coherence tomography (OCT) and laser-induced fluorescence (LIF) have been evaluated for human colorectal cancer. This study applies these technologies to a murine model of colorectal adenoma. STUDY DESIGN/MATERIALS AND METHODS: The lower colon of 10 Apc(Min) and two C57BL/6J mice was surveyed over five 4-week intervals using a prototype 2.0 mm diameter OCT-LIF endoscope-based system. Four categories were histologically classified: control C57BL/6J, adenomatous, non-diseased regions of adenomatous, and non-diseased Apc(Min). OCT images were compared to histology. Spectra from the four categories were compared via the Student's t-test. RESULTS: Three Apc(Min) and two control mice completed the study. One adenoma was histologically identified; OCT visualized mucosal thickening/abnormal mass development over the imaging timepoints. LIF spectral comparisons revealed decreased 405 nm intensity and the presence of a peak at 680 nm in the adenomatous Apc(Min). CONCLUSIONS: These preliminary data indicate endoscopic OCT-LIF has the potential to identify colorectal adenomas in murine models. |
