| First Author | Luongo C | Year | 1994 |
| Journal | Cancer Res | Volume | 54 |
| Issue | 22 | Pages | 5947-52 |
| PubMed ID | 7954427 | Mgi Jnum | J:21369 |
| Mgi Id | MGI:69358 | Citation | Luongo C, et al. (1994) Loss of Apc+ in intestinal adenomas from Min mice. Cancer Res 54(22):5947-52 |
| abstractText | Allelic loss at the Apc locus in spontaneously occurring intestinal adenomas from mice heterozygous for the ApcMin nonsense mutation was analyzed using a site-specific quantitative polymerase chain reaction assay. All 97 of the intestinal adenomas analyzed showed extensive loss of the wild-type Apc (Apc+) allele. Quantitative polymerase chain reaction analysis of loci linked to Apc indicated loss of the chromosome carrying Apc+. Only one copy of the homologue carrying ApcMin remained in the intestinal adenomas. Possible reasons for the difference in the mechanism of Apc+ loss between human and Min mouse intestinal adenomas are discussed. |
