| First Author | Montagna C | Year | 2019 |
| Journal | Cell Death Dis | Volume | 10 |
| Issue | 5 | Pages | 354 |
| PubMed ID | 31043586 | Mgi Jnum | J:289693 |
| Mgi Id | MGI:6434601 | Doi | 10.1038/s41419-019-1584-3 |
| Citation | Montagna C, et al. (2019) nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis. Cell Death Dis 10(5):354 |
| abstractText | Neuronal nitric oxide synthase (nNOS) plays a crucial role in the maintenance of correct skeletal muscle function due, at least in part, to S-nitrosylation of specific protein targets. Similarly, we recently provided evidence for a muscular phenotype in mice lacking the denitrosylase S-nitrosoglutathione reductase (GSNOR). Here, we demonstrate that nNOS and GSNOR are concomitantly expressed during differentiation of C2C12. They colocalizes at the sarcolemma and co-immunoprecipitate in cells and in myofibers. We also provide evidence that GSNOR expression decreases in mouse models of muscular dystrophies and of muscle atrophy and wasting, i.e., aging and amyotrophic lateral sclerosis, suggesting a more general regulatory role of GSNOR in skeletal muscle homeostasis. |
