| First Author | Anderson JL | Year | 2004 |
| Journal | Brain Res | Volume | 1019 |
| Issue | 1-2 | Pages | 289-92 |
| PubMed ID | 15306266 | Mgi Jnum | J:91994 |
| Mgi Id | MGI:3051443 | Doi | 10.1016/j.brainres.2004.06.011 |
| Citation | Anderson JL, et al. (2004) Long-term depression is reduced in cerebellar Purkinje cells of dystrophin-deficient mdx mice. Brain Res 1019(1-2):289-92 |
| abstractText | The mdx (muscular dystrophy X-linked) mouse is a model for human Duchenne muscular dystrophy (DMD) and is characterized by the absence of the cytoskeletal protein dystrophin. Using a cerebellar slice preparation, we show that postsynaptically mediated long-term depression (LTD) is significantly reduced in mdx Purkinje cells, while presynaptically mediated paired-pulse facilitation (PPF) is normal. This disruption of LTD could contribute to the cognitive deficit in boys with Duchenne muscular dystrophy. |
