| First Author | Schmidt M | Year | 2021 |
| Journal | Front Cell Dev Biol | Volume | 9 |
| Pages | 721543 | PubMed ID | 34676210 |
| Mgi Jnum | J:312453 | Mgi Id | MGI:6785186 |
| Doi | 10.3389/fcell.2021.721543 | Citation | Schmidt M, et al. (2021) Stimulation of Non-canonical NF-kappaB Through Lymphotoxin-beta-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle. Front Cell Dev Biol 9:721543 |
| abstractText | Myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle are cellular processes under tight control of various signaling pathways. Here, we investigated the role of non-canonical NF-kappaB signaling in myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle. We stimulated non-canonical NF-kappaB signaling with an agonistically acting antibody of the lymphotoxin beta receptor (LTbetaR). Interestingly, we found that stimulation of non-canonical NF-kappaB signaling through the LTbetaR agonist impairs myogenic differentiation, muscle stem cell function, and regeneration of skeletal muscle. Furthermore, we show that stimulation of non-canonical NF-kappaB signaling by the LTbetaR agonist coincides with activation of canonical NF-kappaB signaling. We suggest a direct crosstalk between canonical and non-canonical NF-kappaB signaling during myogenic differentiation which is required for proper myogenic differentiation and thereby regeneration of skeletal muscle. |
