| First Author | Liadaki K | Year | 2012 |
| Journal | J Histochem Cytochem | Volume | 60 |
| Issue | 1 | Pages | 31-44 |
| PubMed ID | 22205679 | Mgi Jnum | J:196791 |
| Mgi Id | MGI:5489887 | Doi | 10.1369/0022155411428991 |
| Citation | Liadaki K, et al. (2012) beta4 integrin marks interstitial myogenic progenitor cells in adult murine skeletal muscle. J Histochem Cytochem 60(1):31-44 |
| abstractText | Skeletal muscle growth and its regeneration following injury rely on myogenic progenitor cells, a heterogeneous population that includes the satellite cells and other interstitial progenitors. The present study demonstrates that surface expression of beta4 integrin marks a population of vessel-associated interstitial muscle progenitor cells. Muscle beta4 integrin-positive cells do not express myogenic markers upon isolation. However, they are capable of undergoing myogenic specification in vitro and in vivo: beta4 integrin cells differentiate into multinucleated myotubes in culture dishes and contribute to muscle regeneration upon delivery into diseased mice. Subfractionation of beta4 integrin-expressing cells based on CD31 expression does not further enrich for myogenic precursors. These findings support the expression of beta4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle. |
