| First Author | Kana V | Year | 2019 |
| Journal | J Exp Med | Volume | 216 |
| Issue | 10 | Pages | 2265-2281 |
| PubMed ID | 31350310 | Mgi Jnum | J:280062 |
| Mgi Id | MGI:6364232 | Doi | 10.1084/jem.20182037 |
| Citation | Kana V, et al. (2019) CSF-1 controls cerebellar microglia and is required for motor function and social interaction. J Exp Med 216(10):2265-2281 |
| abstractText | Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in the cerebellum is unknown. Here we show that human and mouse cerebellar microglia express a unique molecular program distinct from forebrain microglia. Cerebellar microglial identity was driven by the CSF-1R ligand CSF-1, independently of the alternate CSF-1R ligand, IL-34. Accordingly, CSF-1 depletion from Nestin(+) cells led to severe depletion and transcriptional alterations of cerebellar microglia, while microglia in the forebrain remained intact. Strikingly, CSF-1 deficiency and alteration of cerebellar microglia were associated with reduced Purkinje cells, altered neuronal function, and defects in motor learning and social novelty interactions. These findings reveal a novel CSF-1-CSF-1R signaling-mediated mechanism that contributes to motor function and social behavior. |
