| First Author | Tacke R | Year | 2015 |
| Journal | Sci Rep | Volume | 5 |
| Pages | 10055 | PubMed ID | 26091486 |
| Mgi Jnum | J:251522 | Mgi Id | MGI:6101587 |
| Doi | 10.1038/srep10055 | Citation | Tacke R, et al. (2015) The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus. Sci Rep 5:10055 |
| abstractText | Tissue macrophages function to maintain homeostasis and regulate immune responses. While tissue macrophages derive from one of a small number of progenitor programs, the transcriptional requirements for site-specific macrophage subset development are more complex. We have identified a new tissue macrophage subset in the thymus and have discovered that its development is dependent on transcription factor NR4A1. Functionally, we find that NR4A1-dependent macrophages are critically important for clearance of apoptotic thymocytes. These macrophages are largely reduced or absent in mice lacking NR4A1, and Nr4a1-deficient mice have impaired thymocyte engulfment and clearance. Thus, NR4A1 functions as a master transcription factor for the development of this novel thymus-specific macrophage subset. |
