| First Author | Mandik L | Year | 1995 |
| Journal | Eur J Immunol | Volume | 25 |
| Issue | 11 | Pages | 3148-54 |
| PubMed ID | 7489756 | Mgi Jnum | J:30282 |
| Mgi Id | MGI:77795 | Doi | 10.1002/eji.1830251124 |
| Citation | Mandik L, et al. (1995) Fas receptor expression on B-lineage cells. Eur J Immunol 25(11):3148-54 |
| abstractText | Mice homozygous for the lpr mutation have B and T cell defects and develop autoantibodies, suggesting that lpr plays a role in their genesis. The lpr defect has been identified as a mutation in the apoptosis-associated Fas receptor (FasR) gene. To begin to define the role of FasR in B cells, we have surveyed FasR expression on B-lineage cells from early progenitors in the bone marrow through their maturation in the periphery. Contrary to some reports, we found that FasR is expressed on B cells at all stages of their development and is highest on germinal center B cells. FasR is not expressed on lpr!lpr-derived cells. These data are consistent with the idea that lpr/lpr mice have an intrinsic B cell defect that may be manifested in developing as well as peripheral B cells. An unexpected finding is that B-1 (CD5) B cells do not constitutively express FasR: FasR becomes detectable on B-1 B cells only after activation. |
