| First Author | Oura R | Year | 2013 |
| Journal | J Immunol | Volume | 190 |
| Issue | 2 | Pages | 578-85 |
| PubMed ID | 23255359 | Mgi Jnum | J:191713 |
| Mgi Id | MGI:5462469 | Doi | 10.4049/jimmunol.1103794 |
| Citation | Oura R, et al. (2013) Induction of Rapid T Cell Death and Phagocytic Activity by Fas-Deficient lpr Macrophages. J Immunol 190(2):578-85 |
| abstractText | Peripheral T cells are maintained by the apoptosis of activated T cells through the Fas-Fas ligand system. Although it is well known that normal T cells fail to survive in the Fas-deficient immune condition, the molecular mechanism for the phenomenon has yet to be elucidated. In this study, we demonstrate that rapid cell death and clearance of normal T cells were induced by Fas-deficient lpr macrophages. Transfer of normal T cells into lpr mice revealed that Fas expression on donor T cells was promptly enhanced through the IFN-gamma/IFN-gammaR. In addition, Fas ligand expression and phagocytic activity of lpr macrophages were promoted through increased NF-kappaB activation. Controlling Fas expression on macrophages plays an essential role in maintaining T cell homeostasis in the peripheral immune system. Our data suggest a critical implication to the therapeutic strategies such as transplantation and immunotherapy for immune disorder or autoimmunity related to abnormal Fas expression. |
