| First Author | Valujskikh A | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 9 | Pages | 844-51 |
| PubMed ID | 12172545 | Mgi Jnum | J:183981 |
| Mgi Id | MGI:5319696 | Doi | 10.1038/ni831 |
| Citation | Valujskikh A, et al. (2002) Cross-primed CD8(+) T cells mediate graft rejection via a distinct effector pathway. Nat Immunol 3(9):844-51 |
| abstractText | To prevent bystander destruction of healthy host tissues, cytotoxic CD8(+) T lymphocytes are fitted with specific receptors that direct their destructive forces specifically against chosen targets. We show here, however, that anti-H-Y monospecific, H-2(b-restricted MataHari CD8(+) T cells reject H-2(k) male skin grafts, with which they cannot directly interact. Such rejection is interferon-gamma-dependent and only occurs if the recipient endothelium expresses H-2(b). The findings suggest an alternate indirect effector pathway that requires processing and presentation of the donor H-Y antigen by recipient endothelium and have implications for both transplantation and autoimmune disease. |
