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Publication : Cochlear IgG in the C3H/lpr autoimmune strain mouse.

First Author  Wong ML Year  1992
Journal  Hear Res Volume  59
Issue  1 Pages  93-100
PubMed ID  1629052 Mgi Jnum  J:943
Mgi Id  MGI:49475 Doi  10.1016/0378-5955(92)90106-w
Citation  Wong ML, et al. (1992) Cochlear IgG in the C3H/lpr autoimmune strain mouse. Hear Res 59(1):93-100
abstractText  The inner ear of the C3H/lpr autoimmune strain mouse was evaluated to identify potential mechanisms by which systemic autoimmune disease interferes with auditory function. The inner ears were immunohistochemically stained for IgG at ages before (2 months) and after (6-10 months) autoimmune disease onset and compared to age-matched nonautoimmune C3H/HeJ controls. Immunoreactivity for IgG was not seen in the 2 month C3H/lpr autoimmune mice or in either age group of the C3H/HeJ controls. On the other hand, all older C3H/lpr mice showed reaction product in the vessels of the cochlea, particularly the stria vascularis and bony capsule. Less frequent sites of staining were the geniculate ganglion, marrow cavities of the bony capsule, tensor tympani muscle, and on one occasion, a hair cell of the organ of Corti. These findings indicate that IgG is widespread within the cochlea and its vessels during systemic autoimmune disease and not directed against any specific sensorineural structure. This suggests a generalized or indirect mechanism whereby such systemic disease affects the inner ear.
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