| First Author | Ohno T | Year | 2005 |
| Journal | Immunogenetics | Volume | 57 |
| Issue | 3-4 | Pages | 293-6 |
| PubMed ID | 15900502 | Mgi Jnum | J:98532 |
| Mgi Id | MGI:3578617 | Doi | 10.1007/s00251-005-0791-5 |
| Citation | Ohno T, et al. (2005) Fas has a role in cerebral malaria, but not in proliferation or exclusion of the murine parasite in mice. Immunogenetics 57(3-4):293-6 |
| abstractText | We examined the susceptibility of murine Fas-deficient mutants to malaria infection in order to investigate the role of Fas in an experimental murine model of cerebral malaria (CM). We infected mice of B6 and CBA wild-type and mutant backgrounds with Plasmodium berghei ANKA. The incidence of CM in the mutant mice (B6-lpr, CBA-lpr(cg)) was decreased by about 50% compared with wild-type control strains at 2 weeks after infection. We did not observe significant differences of parasitemia during a murine malaria infection with nonlethal Plasmodium yoelii 17XNL between wild-type and lymphoproliferative (lpr) mutant mice of C3H and MRL genetic backgrounds, although B6-lpr mice exhibited significantly higher parasitemia than did B6 mice 12 to 18 days after infection. These results suggest Fas has a possible role in CM but may not play a major role in the proliferation or exclusion of a murine malaria parasite in a nonlethal infection. |
