| First Author | Haraldsson MK | Year | 2008 |
| Journal | Immunity | Volume | 28 |
| Issue | 1 | Pages | 40-51 |
| PubMed ID | 18199416 | Mgi Jnum | J:131363 |
| Mgi Id | MGI:3773559 | Doi | 10.1016/j.immuni.2007.11.023 |
| Citation | Haraldsson MK, et al. (2008) The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity 28(1):40-51 |
| abstractText | Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the Coro1a(Lmb3) mutation in T cells. Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases. |
