| First Author | Rowley DA | Year | 1995 |
| Journal | J Exp Med | Volume | 181 |
| Issue | 5 | Pages | 1875-80 |
| PubMed ID | 7722461 | Mgi Jnum | J:24955 |
| Mgi Id | MGI:72670 | Doi | 10.1084/jem.181.5.1875 |
| Citation | Rowley DA, et al. (1995) Autoantibodies produced spontaneously by young 1pr mice carry transforming growth factor beta and suppress cytotoxic T lymphocyte responses. J Exp Med 181(5):1875-80 |
| abstractText | Young MRL/MPJ-lpr (lpr) mice 8-12 wk old challenged with alloantigen had significantly lower specific cytolytic T lymphocyte (CTL) responses than control MRL/MPJ +/+ mice. Serum from lpr mice compared with serum from ++ or normal C3H mice powerfully suppressed CTL responses in mixed lymphocyte cultures (MLC); absorbing lpr serum on protein G, adding antibody against transforming growth factor beta (TGF-beta) to cultures or dissociating immunoglobulin G (IgG) and TGF-beta before additions to cultures prevented suppression. Apparently autoantibody, similar to IgG produced by normal mice in response to immunization, carries TGF-beta which suppresses CTL responses in vivo and in vitro. |
