| First Author | Schirmer B | Year | 2015 |
| Journal | PLoS One | Volume | 10 |
| Issue | 10 | Pages | e0140173 |
| PubMed ID | 26465326 | Mgi Jnum | J:243682 |
| Mgi Id | MGI:5909381 | Doi | 10.1371/journal.pone.0140173 |
| Citation | Schirmer B, et al. (2015) Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice. PLoS One 10(10):e0140173 |
| abstractText | The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRLlpr mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time, lymphadenopathy, constitutive interferon-gamma production, and frequency of CD3+B220+ abnormal T cells were without differences. We conclude that in the systemic lupus erythematosus syndrom IL-18 is involved specifically in the renal pathogenesis. |
