| First Author | Zhang Z | Year | 2009 |
| Journal | J Immunol | Volume | 183 |
| Issue | 5 | Pages | 3160-9 |
| PubMed ID | 19657089 | Mgi Jnum | J:151862 |
| Mgi Id | MGI:4355458 | Doi | 10.4049/jimmunol.0900385 |
| Citation | Zhang Z, et al. (2009) The role of IL-23/IL-17 axis in lupus nephritis. J Immunol 183(5):3160-9 |
| abstractText | T cells that express IL-17 infiltrate the kidneys of patients with systemic lupus erythematosus. A significant proportion of these cells are CD3(+)CD4(-)CD8(-) double-negative T cells. In this study, we show that double-negative T cells from MRL/lpr mice express high amounts of IL-17 and that as disease progressively worsens, the expression of IL-17 and of IL-23 receptor in lymphocytes from these mice increases. Lymph node cells from lupus-prone mice, but not control mice, treated in vitro with IL-23 induce nephritis when transferred to non-autoimmune, lymphocyte-deficient Rag-1(-/-) mice. Kidney specimens from these recipient mice show significant Ig and complement deposition. The data indicate that an aberrantly active IL-23/IL-17 axis contributes to the development of nephritis in lupus-prone mice. |
